decoupleR & Transcription Factory Activity Inference: pvalue or padj?
0
0
Entering edit mode
3 months ago
OST ▴ 10

Hello! I recently came across decoupleR for transcription factor activity inference in bulk RNA-seq (https://www.bioconductor.org/packages/release/bioc/vignettes/decoupleR/inst/doc/tf_bk.html).

I was wondering why do they use p-values, as opposed to adjusted pvalues, in their analysis of inferring infer pathway activities from the t-values of the DEGs between KO and WT? Is there a specific reason to use raw (unadjusted) pvalues in this context?

Thanks!

pvalue padj decoupleR • 233 views
ADD COMMENT

Login before adding your answer.

Traffic: 2187 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6