I downloaded a differential gene expression summary data table like this from brainSCOPE.
All I need are the
log2FoldChange column. However, each gene's data is split into multiple different cell types, as indicated in the
cell_type column. These are too many cell types to work with- so I just want to merge some cell subtypes into larger cell types- e.g., I want to merge Vip, Sst, Pvalb cells into just "interneuron".
In this case, can I simply get the mean of log2FoldChange values of Vip, Sst, Pvalb for each gene? I don't care about p-values because I will analyze log2FC values with threshold-agnostic methods.