Entering edit mode
14 days ago
Hansen_869
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80
Hi,
I have a protein modelled in alphafold2. The protein has a couple of substituted amino acids, to try and improve its solubility and increase its hydrophilicity
- How would you go about measuring if it is in fact more soluble and more hydrophilic after the substitutions, in comparison to the original non-substituted protein?
- Are there any tools that can predict if the substitutions might negatively alter the structure of the protein? Such as increased aggregation or steric hindrance.
Thank you!
Best, A
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