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10.0 years ago
kanwarjag
★
1.2k
I understand that somatic mutations occur during the development of cell and are not transferred from one generation to other.
I analyzed a whole genome seq data It showed me that there are 30 variations which are specifically somatics in matched tumor vs normal . Of these, 30 only 1 is in exonic region rest are in either promoter, intron, UTR regions. I could not find out how somatic mutations are identified in non exoinc regions. In such case are non exonic mutations with somatic status may be equally valuable or not.
What was the approach that you used to identify the somatic mutations? What is your question?