687 results • Page 3 of 23
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
Of course, having a newer version of the nanopore base caller will have some impact. The accuracy obviously constantly improves, and in long-running projects like ours, we now have samples with Guppy4, Guppy 5, and Guppy 6 base caller versions.I reasoned that it would probably be a confounder, but we mainly look at structural variation.… Continue reading Beware of confounding basecaller versions go to blog
Rare genetic diseases were one of the first beneficiaries of the high-throughput sequencing revolution. Gene discovery in rare disease was once a laborious endeavor that required gene mapping approaches — linkage analysis in dominant pedigrees, or homozygosity mapping in consanguineous families — to narrow the search space, followed by targeted sequencing of coding regions of […] The post A Decade of Gene Discovery in Rare Disease appeared first on KidsGenomics. go to blog
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
Periodically in my work or during writing this blog I come across computational problems that have the aspects of making, at least in my mind, very good teaching problems. Some of the characteristics are that the basic problem is relatively simple to explain, the skills required are reusable on other problems, the concepts are germane to other problems and that the posed problem can be expanded in steps to something much richer. Such problems might even be the nucleus of … go to blog
PacBio has been rolling out announcements around the ASHG meeting and now delivers a huge one: the next generation SMRT instrument “Revio” will roll out next spring and it’s a big step up in throughput. With Revio’s 15X boost in per-run throughput over Sequel IIe, PacBio is touting this as 30X HIFi genomes for under $1K sequencing consumables per genome. Read more » go to blog
I am releasing Cramino today, my first Rust experience. Cramino is a faster replacement for NanoStat, and extracts features from cram and bam files that are useful for quality assessment of long read sequencing data, including read lengths and read identities. The default output looks like below (left), and is generated in 12 minutes for… Continue reading Introducing Cramino: a *fast* QC tool go to blog
I have a new hobby: camera traps, also known as trail cameras. Strapped to trees in my local bushland they sit in wait, firing automatically when triggered by a passing animal. Once in a while, something quite magical happens. The camera model I chose is the Campark T85 which for me, had the right combination … Continue reading Editing metadata in trail camera images using R, magick and exiftool go to blog
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
A $k$-long sequence $P$ is a ($k$,$s$)-open-syncmer, $s\le k$, if $P[1,s]$ is the smallest among all $s$-mers in $P$. Suppose function $\phi$ is a bijective hash function of $k$-long sequences. $P$ is a random ($k$,$s$)-syncmer if $\phi(P)$ is an open syncmer. Because we often map $k$-mers to integers, $\phi$ can take the form of an invertible integer hash function. In practice, $\phi$ does not have to be a bijection. It can also map a sequence to an integer of a … go to blog
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
A week ago, a company calling itself General Inception emerged from stealth as a new concept, which they call an “Igniter company”, to promote the formation of new life sciences company. As described to me in a phone conversation with General Inception CEO Paul Conley, General Inception provides a range of science and business expertise and support to enable embryonic ideas to condense into functional startups. The igniter metaphor Conley offered me is the spark plug of a car: it … go to blog
The Only Thing Clear About Infinity Is It Is Now Complete Long Reads. Illumina told us a new name for Infinity -- Illumina Complete Long Reads -- and an initial pair of products, but didn't reveal anything new about the underlying tech. They threw out a number of claims, but very vague ones. Particularly confusing is that it "isn't synthetic reads". If not, then what is it? Read more » go to blog
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
Command-line interface, or CLI in brief, specifies how a user interacts with a program on the command line. Torsten Seemann wrote a good article on creating CLI. This blog post adds a few more suggestions. 1. Keep the backward compatibility of CLI as much as possible Backward compatibility here means users can upgrade and run a tool without changing the command lines they used in the past. This implies we should not remove or change the meaning of an existing … go to blog
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
A couple of weeks ago I sat down for coffee with a pair of MGI representatives - American Region CEO Yongwei Zhang and Director, Global Business Development Damon Zhang. Since I hadn’t been at AGBT 2022 (my 2023 application already filed!). Yongwei and I had planned to try to catch up the next time he was in Boston area, so I braved our current subway issues (not one, but two major lines shut for extended maintenance!) and covered a range … go to blog
The **Biostar Herald** publishes user submitted links of bioinformatics relevance. It aims to provide a summary of interesting and relevant information you may have missed... go to blog
687 results • Page 3 of 23
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