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3
votes
5
replies
1.5k
views
What kind of systematic bias of sequencing data the following normalization procedure address?
next-gen normalization bias
updated 3.2 years ago by 35k • written 5.8 years ago by ▴ 340
28
votes
9
replies
20k
views
samtools bedcov vs. bedtools coverage
DNA-seq coverage
updated 3.2 years ago by 35k • written 5.5 years ago by ▴ 340
20
votes
16
replies
4.4k
views
Breaking down the reference genome chromosome-wise
fasta reference_genome
updated 4.2 years ago by • 0 • written 7.1 years ago by ▴ 340
0
votes
3
replies
2.6k
views
How to create a pooled normal exome sample?
next-gen sequencing exome copy number analysis
updated 4.2 years ago by ▴ 180 • written 6.4 years ago by ▴ 340
0
votes
0
replies
1.6k
views
Best way to normalize Human BodyMap 2.0 data
RNA-Seq normalization
updated 5.3 years ago by 20 • written 6.1 years ago by ▴ 340
5
votes
5
replies
2.8k
views
what does Num_Probes in a segmentation file refer to?
sequencing
updated 5.7 years ago by ★ 2.8k • written 5.7 years ago by ▴ 340
19
votes
15
replies
4.2k
views
6 follow
What is the best way to make a bam file smaller by removing unwanted information?
next-gen bam sequencing compression
5.9 years ago by Dataman ▴ 340
4
votes
5
replies
3.8k
views
How to create B-allele frequency file for ADTEx?
next-gen sequencing exome adtex
updated 6.4 years ago by 5.6k • written 6.4 years ago by ▴ 340
11
votes
1
reply
3.8k
views
Does one need to sort and index after performing a rmdup in Samtools?
samtools variant alignment sequencing
updated 6.8 years ago by 140k • written 6.8 years ago by ▴ 340
2
votes
1
reply
2.5k
views
Estimating the expected number of reads that overlap a [heterozygous] snp in one window from the read depth, read length and resolution
snp simualtion statistics allele baf
7.2 years ago by Dataman ▴ 340
6
votes
7
replies
2.1k
views
Why is the noise level higher in regions with amplification than regions with deletion in the genome?
dna-seq allele fraction tool snp noise
updated 12 days ago by 35k • written 7.4 years ago by ▴ 340
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