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1
vote
5
replies
2.3k
views
Shannon vs Simpson for TCR diversity estimation
TCR shannon simpson
updated 7 days ago by 81k • written 5.0 years ago by ▴ 750
0
votes
1
reply
149
views
How to reveal real AF of variant if duplicates can't be removed (such as in amplicon-seq)
allele-frequency amplicon-seq
updated 7 days ago by 43k • written 7 days ago by ▴ 750
2
votes
5
replies
3.9k
views
Any tools for predicting binding affinity between TCR and epitode?
prediction TCR cancer
updated 10 weeks ago by • 0 • written 5.9 years ago by ▴ 750
2
votes
2
replies
885
views
Method to detect genome doubling
CNV genome doubling
updated 1 day ago by ★ 1.2k • written 4.4 years ago by ▴ 750
2
votes
6
replies
1.7k
views
Can we get absolute abundance of TCR using TCR-Seq?
TCR-Seq
updated 14 months ago by ▴ 60 • written 5.3 years ago by ▴ 750
0
votes
1
reply
1.6k
views
Wilcoxon test, t-test and negative binomial test for DEG of scRNA-Seq data
scRNA-Seq DEG differential expression
updated 18 months ago by 13k • written 3.5 years ago by ▴ 750
0
votes
0
replies
668
views
Why case-controlled study is more bias prone than cohort study?
case-controlled study cohort study confounder
written 3.4 years ago by ▴ 750
0
votes
0
replies
319
views
Which distribution to choose for ploting mutant allele frequency?
distribution SNV
18 months ago by CY ▴ 750
0
votes
2
replies
3.6k
views
Comment: Comment: Why NB distribution is preferred in RNA-Seq while normal distribution is preferr
23 months ago by CY ▴ 750
0
votes
1
reply
495
views
Reference material for distinguishing focal CNV and chromosome CNV
CNV
updated 2.3 years ago by ★ 2.9k • written 2.3 years ago by ▴ 750
0
votes
1
reply
866
views
What is the well-recognized standard of coverage uniformity
sequencing CNV depth uniformity coverage
updated 2.8 years ago by ★ 2.9k • written 2.8 years ago by ▴ 750
0
votes
0
replies
1.1k
views
Comment: Comment: Detection of CNV(InDel) of intermediate size
2.9 years ago by CY ▴ 750
0
votes
1
reply
710
views
Detection of biallelic mutation (inactivation)
somatic biallelic mutation
updated 2.9 years ago by ▴ 160 • written 2.9 years ago by ▴ 750
4
votes
2
replies
1.6k
views
Forum: Why did expression based subtypng of breast cancer gain much more acceptance than others
RNA-Seq subtyping expression
updated 3.0 years ago by 141k • written 3.1 years ago by ▴ 750
0
votes
0
replies
607
views
Comment: C: Violation of Independence test for differential methylation (DM)
3.1 years ago by CY ▴ 750
0
votes
2
replies
607
views
Violation of Independence test for differential methylation (DM)
methylation differential methylation
3.1 years ago by CY ▴ 750
3
votes
3
replies
1.3k
views
Treat methylation as binary or continuous signal when detecting DMR?
methylation
3.6 years ago by CY ▴ 750
0
votes
1
reply
1.3k
views
Comment: C: Treat methylation as binary or continuous signal when detecting DMR?
3.6 years ago by CY ▴ 750
0
votes
1
reply
2.2k
views
Comment: C: What statistical test for CpG DMR ?
3.6 years ago by CY ▴ 750
5
votes
1
reply
1.2k
views
Is definition of differentially methylated region (DMR) biologically meaningful?
methylation DMR
updated 3.6 years ago by 3.2k • written 3.6 years ago by ▴ 750
0
votes
2
replies
1.1k
views
Defining methylation level of CpG island
methylation CpG island
3.6 years ago by CY ▴ 750
0
votes
0
replies
1.1k
views
Comment: C: Defining methylation level of CpG island
3.6 years ago by CY ▴ 750
0
votes
1
reply
838
views
Comment: C: How to derive sequence of novel transcript identified by Cufflinks
3.6 years ago by CY ▴ 750
0
votes
3
replies
838
views
How to derive sequence of novel transcript identified by Cufflinks
transcript RNA-Seq
3.6 years ago by CY ▴ 750
0
votes
0
replies
487
views
Did and why recent studies show superior predictive power using methylation data on early cancer detection
methylation cancer detection
3.8 years ago by CY ▴ 750
0
votes
0
replies
661
views
Example code of MCMC on somatic variant calling (site specific error model)
Variant calling
3.8 years ago by CY ▴ 750
0
votes
0
replies
466
views
Create synthetic data based on general description of molecular characteristic for modeling
next-gen
4.0 years ago by CY ▴ 750
0
votes
0
replies
3.6k
views
Comment: Comment: Why NB distribution is preferred in RNA-Seq while normal distribution is preferr
4.0 years ago by CY ▴ 750
13
votes
9
replies
3.6k
views
Why NB distribution is preferred in RNA-Seq while normal distribution is preferred in microarray?
RNA-Seq Microarray
updated 23 months ago by ★ 5.8k • written 4.0 years ago by ▴ 750
0
votes
0
replies
973
views
Comment: C: Logit-normal distribution to model variation among biological replicates
4.1 years ago by CY ▴ 750
0
votes
2
replies
973
views
Logit-normal distribution to model variation among biological replicates
rMATS alternative splicing distribution
updated 4.1 years ago by 87k • written 4.1 years ago by ▴ 750
0
votes
1
reply
769
views
How does aligner determine strandness when doing alignment
alignment
4.1 years ago by CY ▴ 750
0
votes
4
replies
1.1k
views
Would curated pathway gene set better being weighted than being binary
RNA-Seq enrichment analysis
updated 4.1 years ago by 20 • written 4.3 years ago by ▴ 750
0
votes
1
reply
848
views
Comment: C: Distinguishing real RNA-editing event from sequencing artifact due to reverse tr
4.1 years ago by CY ▴ 750
0
votes
3
replies
848
views
Distinguishing real RNA-editing event from sequencing artifact due to reverse transcription
RNA-editing sequencing artifact
4.1 years ago by CY ▴ 750
1
vote
2
replies
1.1k
views
Detection of CNV(InDel) of intermediate size
CNV InDel
2.9 years ago by CY ▴ 750
2
votes
3
replies
970
views
Identifying zygosity of somatic deletion
CNV
updated 4.2 years ago by ▴ 460 • written 4.2 years ago by ▴ 750
0
votes
0
replies
970
views
Comment: C: Identifying zygosity of somatic deletion
4.2 years ago by CY ▴ 750
0
votes
1
reply
983
views
Comment: C: In PCA on RNA-Seq data, what does Gaussian distribution refer to?
4.2 years ago by CY ▴ 750
0
votes
3
replies
983
views
In PCA on RNA-Seq data, what does Gaussian distribution refer to?
RNA-Seq PCA Gaussian
updated 4.2 years ago by 104k • written 4.2 years ago by ▴ 750
0
votes
1
reply
12k
views
Comment: C: PCA vs ICA prior to t-SNE or UMAP
4.2 years ago by CY ▴ 750
0
votes
1
reply
12k
views
Comment: C: PCA vs ICA prior to t-SNE or UMAP
4.2 years ago by CY ▴ 750
0
votes
2
replies
1.1k
views
Comment: C: Would curated pathway gene set better being weighted than being binary
4.3 years ago by CY ▴ 750
0
votes
0
replies
2.0k
views
Comment: C: bwa XA field: What is the procedure for the binning of all but one alternative a
4.3 years ago by CY ▴ 750
1
vote
1
reply
1.3k
views
Comment: C: Arm-level SCNA does not change mRNA expression level?
4.4 years ago by CY ▴ 750
0
votes
0
replies
904
views
Comment: C: Does variant enrichment analysis make sense?
4.4 years ago by CY ▴ 750
0
votes
2
replies
904
views
Does variant enrichment analysis make sense?
enrichment analysis somatic variant expression
4.4 years ago by CY ▴ 750
6
votes
6
replies
1.3k
views
Arm-level SCNA does not change mRNA expression level?
CNV SCNA expression
4.4 years ago by CY ▴ 750
2
votes
7
replies
1.3k
views
Why can we still be able to continuously discover new cancer driver bioinformatically these days?
driver gene cancer
4.4 years ago by CY ▴ 750
2
votes
0
replies
1.3k
views
Comment: C: Arm-level SCNA does not change mRNA expression level?
4.4 years ago by CY ▴ 750
276 results • Page 1 of 6
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