User: michealsmith
michealsmith • 740
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Posts by michealsmith
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... Many thanks. I just briefly read DeepWAS, it seems it first implement deep-learning-based DeepSEA to annotate functional SNP, then simply apply logistic regression to classify disease/control. This is good enough, but my question is looking for work that directly apply deep learning for classificati ...
written 2.7 years ago by
michealsmith • 740
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... We know in recent several years very quickly deep learning (We could see as advanced multi-layer neural network) has achieved success in picture recognition, which could revolutionize medical diagnosis for example neurological disease diagnosis based on fMRI data.
I'm genetics person for complex d ...
written 2.7 years ago by
michealsmith • 740
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2.7 years ago by
Philipp Bayer ♦ 6.5k
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... Yes, there are.
But the read pair orientation doesn't make sense to me here that they suggests circular RNA.
...
written 2.8 years ago by
michealsmith • 740
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... The read pairs are mapped onto two exons, which are unique sequence. .So mapping is perfect. However, I just put an update to post; the middle intron is highly repetitive; which makes me feel possibly the intron is doing strange things to induce structural change? ...
written 2.8 years ago by
michealsmith • 740
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... Yes the remaining are normal (FR), but the coverage here is around 100X ...
written 2.8 years ago by
michealsmith • 740
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... Scale is around 1-2kb.
I'm wondering if "strange things" indicate functional noncoding RNA, which is usually expressed in low level ...
written 2.8 years ago by
michealsmith • 740
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... Yes I also think about circular RNA; but circular RNA usually indicated by opposite-oriented read pairs facing outward(just like tandem duplication). I'm newcomer to circular RNA, maybe this also indicates circular RNA? ...
written 2.8 years ago by
michealsmith • 740
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... No, only small subsets are like this. Just normal standard Illumina paired-end sequencing; no strand-specificity ...
written 2.8 years ago by
michealsmith • 740
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... Hi biostarers, please see the attached picture from RNA-seq of total RNA; that read pairs with the same orientation (RR) that span two adjacent exons. (Supposedly we should see opposite orientation LR for paired-end reads)
I know this indicates inversion for DNA sequencing; but what about in RNA-se ...
written 2.8 years ago by
michealsmith • 740
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... Hi, I would like to get very accurate quantification of the amount of different alleles of short tandem repeats.
For example in DNA pool, at one locus, there could be 20% CA, 50% CACA， 30% CACACA,
so what could I do？I don't think general SYBR green qPCR could work ...
written 3.1 years ago by
michealsmith • 740
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