Latest
Open
RNA-Seq
ChIP-Seq
SNP
Assembly
Tutorials
Tools
Jobs
Forum
Planet
All »
Home
Log In

User: michealsmith

gravatar for michealsmith
michealsmith • 740
Reputation:
740
Status:
Trusted
Location:
Last seen:
6 months ago
Joined:
6 years, 10 months ago
Email:
s****@gmail.com

about me

Posts by michealsmith

<prev • 94 results • page 1 of 10 • next >
0
votes
1
answer
1.8k
views
1
answers
Comment: C: Deep learning for genetics model of polygenic complex disease.
... Many thanks. I just briefly read DeepWAS, it seems it first implement deep-learning-based DeepSEA to annotate functional SNP, then simply apply logistic regression to classify disease/control. This is good enough, but my question is looking for work that directly apply deep learning for classificati ...
written 23 months ago by michealsmith • 740
0
votes
1
answer
1.8k
views
1
answer
Deep learning for genetics model of polygenic complex disease.
... We know in recent several years very quickly deep learning (We could see as advanced multi-layer neural network) has achieved success in picture recognition, which could revolutionize medical diagnosis for example neurological disease diagnosis based on fMRI data. I'm genetics person for complex d ...
deep learning disease genetics machine learning written 23 months ago by michealsmith • 740 • updated 23 months ago by Philipp Bayer ♦ 5.9k
0
votes
0
answers
818
views
0
answers
Comment: C: Abnormal pair orientation in RNA-seq data
... Yes, there are. But the read pair orientation doesn't make sense to me here that they suggests circular RNA. ...
written 23 months ago by michealsmith • 740
0
votes
0
answers
818
views
0
answers
Comment: C: Abnormal pair orientation in RNA-seq data
... The read pairs are mapped onto two exons, which are unique sequence. .So mapping is perfect. However, I just put an update to post; the middle intron is highly repetitive; which makes me feel possibly the intron is doing strange things to induce structural change? ...
written 23 months ago by michealsmith • 740
0
votes
0
answers
818
views
0
answers
Comment: C: Abnormal pair orientation in RNA-seq data
... Yes the remaining are normal (FR), but the coverage here is around 100X ...
written 23 months ago by michealsmith • 740
0
votes
0
answers
818
views
0
answers
Comment: C: Abnormal pair orientation in RNA-seq data
... Scale is around 1-2kb. I'm wondering if "strange things" indicate functional noncoding RNA, which is usually expressed in low level ...
written 23 months ago by michealsmith • 740
0
votes
0
answers
818
views
0
answers
Comment: C: Abnormal pair orientation in RNA-seq data
... Yes I also think about circular RNA; but circular RNA usually indicated by opposite-oriented read pairs facing outward(just like tandem duplication). I'm newcomer to circular RNA, maybe this also indicates circular RNA? ...
written 23 months ago by michealsmith • 740
0
votes
0
answers
818
views
0
answers
Comment: C: Abnormal pair orientation in RNA-seq data
... No, only small subsets are like this. Just normal standard Illumina paired-end sequencing; no strand-specificity ...
written 23 months ago by michealsmith • 740
2
votes
0
answers
818
views
7 follow
0
answers
Abnormal pair orientation in RNA-seq data
... Hi biostarers, please see the attached picture from RNA-seq of total RNA; that read pairs with the same orientation (RR) that span two adjacent exons. (Supposedly we should see opposite orientation LR for paired-end reads) I know this indicates inversion for DNA sequencing; but what about in RNA-se ...
rna-seq inversion igv written 23 months ago by michealsmith • 740
0
votes
0
answers
615
views
0
answers
Allele-specific quantification methods for short tandem repeats?
... Hi, I would like to get very accurate quantification of the amount of different alleles of short tandem repeats. For example in DNA pool, at one locus, there could be 20% CA, 50% CACA， 30% CACACA, so what could I do？I don't think general SYBR green qPCR could work ...
allele microsatellite qpcr pcr written 2.3 years ago by michealsmith • 740

Latest awards to michealsmith

Popular Question 23 months ago, created a question with more than 1,000 views. For High-Quality Zebrafish Dbsnp Database
Popular Question 23 months ago, created a question with more than 1,000 views. For What Genetic Marker To Use To Infer Pedigree From Sequencing Data?
Popular Question 23 months ago, created a question with more than 1,000 views. For Career plan---Bench+bioinformatics or pure bioinformatics?
Popular Question 23 months ago, created a question with more than 1,000 views. For Stop-Gain Mutation Predicted As Benign By Sift/Polyphen2?
Student 23 months ago, asked a question with at least 3 up-votes. For How To Call Snp From .Ab1 Files Of Sanger Sequencing?
Great Question 23 months ago, created a question with more than 5,000 views. For Stop-Gain Mutation Predicted As Benign By Sift/Polyphen2?
Great Question 23 months ago, created a question with more than 5,000 views. For How To Call Snp From .Ab1 Files Of Sanger Sequencing?
Popular Question 23 months ago, created a question with more than 1,000 views. For Rare Variants Study Using Next-Gen Sequencing Data
Popular Question 23 months ago, created a question with more than 1,000 views. For Ibd Calculation For Small Familial Pedigrees
Popular Question 23 months ago, created a question with more than 1,000 views. For Gatk3 Vs Dindel For Small Indel Calling
Great Question 23 months ago, created a question with more than 5,000 views. For Select Certain Column From Vcf File
Popular Question 23 months ago, created a question with more than 1,000 views. For Identity-By-Descent Used To Narrow Down Targets From Exome Sequencing Data
Popular Question 23 months ago, created a question with more than 1,000 views. For Gatk3 Vs Dindel For Small Indel Calling
Great Question 2.7 years ago, created a question with more than 5,000 views. For Select Certain Column From Vcf File
Great Question 2.7 years ago, created a question with more than 5,000 views. For Stop-Gain Mutation Predicted As Benign By Sift/Polyphen2?
Student 2.7 years ago, asked a question with at least 3 up-votes. For Tools For De Novo Assembly For Exome Sequencing Data
Student 2.8 years ago, asked a question with at least 3 up-votes. For Pipeline of structural variation calling using multiple tools for multiple samples
Popular Question 2.8 years ago, created a question with more than 1,000 views. For Gatk3 Vs Dindel For Small Indel Calling
Popular Question 2.9 years ago, created a question with more than 1,000 views. For Gatk3 Vs Dindel For Small Indel Calling
Great Question 2.9 years ago, created a question with more than 5,000 views. For Stop-Gain Mutation Predicted As Benign By Sift/Polyphen2?
Popular Question 2.9 years ago, created a question with more than 1,000 views. For The "Rareness" Of Two Adjacent Nonsynonymous Mutations.
Good Question 2.9 years ago, asked a question that was upvoted at least 5 times. For Why Is Gwas Underpowered To Detect Association In Rare Variants?
Student 3.0 years ago, asked a question with at least 3 up-votes. For Career Plan: Be A Dual Benchworker And Bioinformatician
Good Question 3.0 years ago, asked a question that was upvoted at least 5 times. For Why Is Gwas Underpowered To Detect Association In Rare Variants?
Appreciated 3.0 years ago, created a post with more than 5 votes. For Career Plan: Be A Dual Benchworker And Bioinformatician
Content
Help
Access
Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 795 users visited in the last hour