User: ashishbansal12300
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Posts by ashishbansal12300
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Answer:
A: Profile Hidden Markov Models
... Profile HMMs are a model-based alternative to the ad-hoc multiple alignment approaches common for sequence family modeling. Since different multiple alignment software packages can yield very different alignments, use of the profile HMM approach is more robust than relying on a single multiple align ...
written 21 months ago by
ashishbansal12300 • 0
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... Genome-sequencing studies indicate that all humans carry many genetic variants predicted to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy in the human genome. Here we apply stringent filters to 2951 putative LoF variants obtained from 185 human genomes to det ...
written 21 months ago by
ashishbansal12300 • 0
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... The human microbiome substantially affects many aspects of human physiology, including metabolism, drug interactions and numerous diseases. This realization, coupled with ever-improving nucleotide sequencing technology, has precipitated the collection of diverse data sets that profile the microbiome ...
written 21 months ago by
ashishbansal12300 • 0
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... These options are used to specify the input and output files.
INPUT FILE OPTIONS
--vcf
This option defines the VCF file to be processed. VCFtools expects files in VCF format v4.0, v4.1 or v4.2. The latter two are supported with some small limitations. If the user provides a dash character ’-’ as ...
written 21 months ago by
ashishbansal12300 • 0
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... The best bioinformatician are:
1. Highly Skilled - programming skills, experience with the biological software and tools.
The biological data won’t illuminate much if the scientist analysing it doesn’t possess practical programming skills, experience with the biological software and tools and a th ...
written 21 months ago by
ashishbansal12300 • 0
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