User: ml1

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ml110
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Posts by ml1

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Comment: C: Validatingm Polygenic Risk Scores from PRSice
... As Sam states - a negative value would suggest a protective score. I'd just been querying likely validity in scores which move from increasing risk to being protective at differing p-values (for the same individual). I think I just don't have enough data for it to be meaningful. If you know that y ...
written 5 weeks ago by ml110
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Comment: C: Validatingm Polygenic Risk Scores from PRSice
... thanks for your help! ...
written 5 weeks ago by ml110
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Comment: C: Validatingm Polygenic Risk Scores from PRSice
... Thanks Sam. Just to get some final advice - if I did manage to get a bigger sample, how would I validate the results I get out of PRSice if I'm unable to do out-of-sample prediction or cross-validation? ...
written 5 weeks ago by ml110
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Comment: C: Validatingm Polygenic Risk Scores from PRSice
... I see! Reassuring to know there aren't any obvious errors at least. I used the 1K genome to show the limited population stratification in the sample - is utilising a reference panel similar? Just for my learning, could you point me to any resource about using --ld option? I'm not sure how to gener ...
written 5 weeks ago by ml110
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Comment: C: Validatingm Polygenic Risk Scores from PRSice
... Hi Sam, Thanks for your reply- great to get advice from you! The cohort I'm using has about 80 cases and 150 controls. I removed the controls who were related to cases, and then after other QC, I ended up with 49 cases and 56 controls. Perhaps this is just too small? It's a wholly white (Northern ...
written 5 weeks ago by ml110
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Validatingm Polygenic Risk Scores from PRSice
... Hi, Hope someone may be able to point me in the right direction! I've generated some polygenic risk scores for schizophrenia in a cohort of individuals with borderline intellectual disability. Trying to figure out a way to validate the scores I'm getting out of PRSice. Is there a way to do this? ...
prsice prs genetics plink written 6 weeks ago by ml110 • updated 5 weeks ago by Sam3.0k

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