Can I use VarScan2 CNV using non normal-tumor pair?

Question

[ruddae43]

hello.

Now I'm using the Varscan2 to see CNV from whole exome sequencing data.

However, Some of my samples are not matched. I just have seven normal-tumor pair 20 tumor only samples.

So, is it okay to check the CNV compared to the average normal sample with the tumor the only sample using the VasScan2?

Thank you.