MMSplice score interpretation
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3.6 years ago
Augusta ▴ 30

Hello,

I am trying to use MMSplice to assess the effect of variants on splicing. However, after reading the paper and https://github.com/gagneurlab/MMSplice_MTSplice#output, I am still not confident in my interpretation of the output. My understanding is that the delta_logit_psi score integrates multiple modules and that a negative score indicates exon skipping. I am however very unsure about the meaning of the other categories (e.g. alt_acceptorIntron, alt_acceptor, alt_exon, pathogenicity) and scores. Unfortunately, I could not find any more resources or examples. Any help would be appreciated!

mmsplice splice-effect-prediction • 1.0k views
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Where you able to find any information. Was wondering the same thing.

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Hi, I would like to know whether you were able to find out those, as I have some doubts regarding the interpretations of these parameters: MMSp_acceptorIntron MMSp_acceptor MMSp_exon MMSp_donor MMSp_donorIntron

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