Gene mutation patterns

Question

[yakumo]

Hi all,

I would like to compare differences in gene mutation frequencies of two groups of patients with prostate cancer (overweight versus normal weight). My goal is to check whether the there are different patterns of affected genes in these two groups. I have a table with WES information, where each row provides information for a Hugo_gene per patient (i.e. multiple rows per patient, see example below):

I have separate information on clinical data per patient IDs, so I know which patients are overweight/normal weight.

What kind of analysis would be most suitable to get a high-level impression on gene patterns and possible differences between those two groups of patients? Could you recommend a tool or R package?

Thanks ever so much!