How To Find Out Whether There Is A Statistical Difference Between Two Sets Of Strings?

Question

[Click downvote]

Let us say I have two sets of nucleotide strings of length 13.

Is there an accepted method of checking if there is any reason to believe they differ in a statistically significant way?

[brentp]

that would depend entirely on what question you are asking and what you use for you null model.

Answer 1

[David]

Classic bioinformatic question. Similarity score between DNA sequence are computed using similarity matrices. The DNA similarity matrices are simpler than the protein one because there is only 4 elements. BLAST use such matrices. (wikipedia)

But the tool of reference is clustalW. It will give you a similarity score.