List Of Naturally Occuring Metabolites/Compounds In Eukaryotes ?

Question

[Sudeep]

Hi All, I am trying to generate a list of naturally occurring compounds/metabolites of eukaryotes. What I am trying to do is to prune Stitch protein chemical interactions to only the interactions between a protein/enzyme and a naturally occurring ligand. The problem I face is that I am not able to find a comprehensive list of naturally occurring compounds, I retrieved some compounds from KEGG "Compounds with biological roles" but this list is rather small, and I was also playing around with search strategies in PubChem with little success. So has anybody tried to doing this ? any suggestions on a search strategy to retrieve a large list of natural ligands ?

Thank you.

Answer 1

[David Westergaard]

I think you'll have to concatenate multiple ressources.

Just to name a few:

• Human Metabolome Database
• KNApSAcK database
• Zinc Natural Product catalog. This is just a collection of databases, and I don't think the entries contain the origin of the natural product

You can probably find other database if you just search Google scholar for "natural product database" or "metabolite database".