Entering edit mode
13 months ago
Binghong
▴
20
Hi guys, I try to analyze the association of SNP and gene using the matrieqtl, but there are 9094 covariates but only 171 samples, the matrixeqtl show that "The number of covariates exceeds the number of samples." I have no idea how to deal with it, how to reduce the number of covariates. Any guidance is appreciated !!
I added the CNV data to the covariates, which increased number of covariates to 9,000
You can only retain a small number of CNVs; or you can compute a SVD of the CNV genotype matrix and include the top PCs
Thanks for your guidance. I will have a try