What is the possibility of Depth (DP) being higher than the coverage

Question

[DareDevil]

Exome sequencing is done at 100x coverage. Germline variants were called using GATK-HaplotypeCaller. When I looked at the VCF files, there are few variants showing higher depth than 100x. Some depth (DP) are like 120, 146, 153 etc

[seidel]

100x coverage is an average for the exome. Individual loci will vary. Did you try calculating the coverage yourself to see how it varies? Or perhaps examine various loci in a browser to see how it varies? If you look at the depth of all your variants from GATK, do you see a distribution of numbers? (i.e. some higher than 100x, some lower?)