Entering edit mode
10 months ago
Barista
▴
10
Hi!
I have difficulties getting the genotype frequency for healthy people. I do not want to download VCF files from gnomAD, because I don't have that much memory on my device. Can someone recommend me something else? I then have to compare the values with my VCF files. How to construct such an API/ from what source or something? I can use both R and Python.
Thank you in advance!
Have you tried Ensembl's REST-API (here)? If you have rs IDs of variants then you could get a population-specific variant frequency using this endpoint enter link description here. For example - https://rest.ensembl.org/vep/human/id/rs56116432
There would be other ways of getting this info from Ensembl's REST-API but this is the only one I could think of at first. Would be helpful for you to browse their page.
Thank you very much! I think this is very helpful, I tried it for some exemplary snp and it seems to work :)