Pathview modifies LFC genes. Is this normal?
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21 months ago
Alex • 0

Hello everyone, I recently found out that when I analysing KEGG pathways and visualizing them using Pathview, genes with a different LFC indicator, different from LFC DESeq2, are mapped (see Figure).

Figure. Genes highlighted in green did not change their own LFC from DESeq2 (value column). As I understand it, if more than one expressed genes is mapped to KEGG gene, then Pathview modifies them. Averaging their LFCs, I guess?

Am I understanding the idea correctly? Besides, is this normal ? Maybe I'm doing something wrong?
gage pathview KEGG R • 512 views
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