Tumour purity and ploidy estimation
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3 months ago
bp22 ▴ 80

Hi all,

I have Whole Exome Sequencing data for multiple tumour samples but do not have matched normal or non-matched normal samples. Are you aware of any bioinformatics tool that can be used for estimation of tumour purity and ploidy of the sample in this case?

I have looked through tools like ASCAT, Sequenza, PureCN and others but they all seem to require matched or non-matched normal samples. Any insight is highly appreciated.

Thank you.

Copy-number Whole-exome-sequencing • 327 views
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Hello bp22,

I'm in the same situation as you, I have Whole Exome Sequencing data for tumour samples only, with no normal samples. I haven't found any tools that don't require matched normal samples or a panel of normals.

Have you found a solution or tool to estimate purity and ploidy of the tumour?

Thanks

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Hi Llyod98,

This issue is still unresolved and I have not been able to find a tool or solution for purity and ploidy estimation when there are no normal samples. Please do let me know in case you come across one.

Thanks.

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