GWAS Phenotypes

Question

[solomoncharles77]

Hi Everyone,

It appears that GWAS can be run for any imaginable phenotype. Surely, there are phenotypes that are not suitable for GWAS. Are there statistical methods for assessing if a phenotype is suitable for GWAS or not?

Answer 1

[韩雨]

In my opinion, the basis of the question is to solve whether the phenotype is regulated by genetics. In the aspect of genetic, the estimation of heritability is essential to evaluate the relationship. The low H2/h2 may means a weak association. In the aspect of biology, is there any path match the central dogma is important. For example, there's no way the genetic variation of maize could influence whether it is used for BBQ or make it cans.