How to convert Illumina SNP ids having mappings to multiple RSID in loci to rsid file ?
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14 months ago
vasank1958 • 0

I am currently trying to convert a Illumina final report generated from GSA3.0 Build 38 into 23&me.

The Illumina GSA3.0 has below columns

['SNP Name',
 'Sample ID',
 'Allele1 - Top',
 'Allele2 - Top',
 'GC Score',
 'Sample Name',
 'Sample Group',
 'Sample Index',
 'SNP Index',
 'SNP Aux',
 'Allele1 - Forward',
 'Allele2 - Forward',
 'Allele1 - Design',
 'Allele2 - Design',
 'Allele1 - AB',
 'Allele2 - AB',
 'Allele1 - Plus',
 'Allele2 - Plus',
 'Chr',
 'Position',
 'GT Score',
 'Cluster Sep',
 'SNP',
 'ILMN Strand',
 'Customer Strand',
 'Top Genomic Sequence',
 'Plus/Minus Strand',
 'Theta',
 'R',
 'X',
 'Y',
 'X Raw',
 'Y Raw',
 'B Allele Freq',
 'Log R Ratio',
 'CNV Value',
 'CNV Confidence']

I have managed to format the data into 23&me form as below

Genotype -> combine Allele1 - plus and Allele2 - plus

chromosome -> Chr

position -> using pyliftover (hg38,hg19) converted positions and stored here

I got stuck in RSID-> ?

There is a file that maps Illumina SNP names to RSID, please refer Loci Name to Rsid

problem is some SNP names have more than 1 rsid and some SNP name has '-' . How to handle this ? can anyone please advice ?

23me illumina conversion GSA3.0 • 477 views
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