Hello community,
I'm excited to introduce TCGA-DDR, a new web-based tool designed to analyze the effects of DNA damage response (DDR) gene loss in the TCGA cohort. DDR pathways play a crucial role in cancer progression, and this tool enables users to explore survival outcomes and genomic landscapes based on DDR deficiencies.
How does it work?
- Create deficiency groups of interest
At this step, the user can decide on how many DDR deficiency groups they are interested it. Each group can have one or multiple loss of DDR genes.
- Survival analysis
The tool provides the option for various survival endpoints in the deficiency groups created by the user.
- DDR footprints or genomic landscape analysis
Here, the users can see the effect of the DDR loss on various genomic features, such as mutational load, ploidy, CNA, loss of heterozygosity etc.
I’m seeking feedback from the community on improving the user experience and overall functionality. I would especially appreciate suggestions on the UI, clarity of content, or any new features that could enhance the tool.
Thank you!
