Hello all,
I’m conducting a personal neurogenomics study and seeking insight into the frequency, behavioral expression, and possible epistatic effects of the following SNP combination within a single individual:
Profile includes: • TPH2 (rs4570625) – TT • GRM2 (rs2030323 or rs2282705) – CC • COMT (rs4680) – AA (Met/Met) • DRD2 (rs1800497, Taq1A) – GG • HTR1A (rs6295) – CC • OXTR (rs53576) – AG • BDNF (rs6265) – CC • MTHFR (rs1801133) – GG
I’m interested in any of the following: • Population frequency estimates or co-occurrence rates across large datasets (gnomAD, 1000 Genomes, etc.) • Documented behavioral phenotypes or psychiatric associations involving multi-SNP interactions in serotonin/dopamine/glutamate pathways • Epistatic relationships between these loci (particularly TPH2–GRM2–COMT) • Existing polygenic behavioral models where combinations of these SNPs are studied for traits like emotional regulation, reward sensitivity, or neuroplasticity • Any recommendations for databases, publications, or computational methods to evaluate such rare SNP stacking
Estimated combined rarity appears to be exceptionally low (approx. <1 in 10 million), especially when GRM2 (CC), TPH2 (TT), and COMT (AA) are considered jointly. I’d like to better understand the statistical and behavioral implications.
Grateful for any references, insights, or redirection to published research.
Thank you, Kyle R.
