Case Western Reserve University: School of Medicine (FAC/RA/RS): School of Medicine - Main Campus (FAC/RA/RS): Neurosciences (FAC/RA/RS)
Location Cleveland, OH
Open Date Sep 17, 2025
https://apply.interfolio.com/173600
Description POSITION OBJECTIVE
The objective of the position is to provide service, training, and help in the study of computational, genomic, cellular, and molecular bases of biological function of the nervous system. The Bioinformatician, Senior Research Associate STS will be responsible for taking on highly interdisciplinary projects and will apply state-of-the-art open-source software for basic and advanced analysis of multiple --omics data. The focus will be on single-cell genomics, RNA/protein interactions, RNA translation, spatial --omics, and chromatin organization. The Bioinformatician, Senior Research Associate will play a leadership role in providing training and guidance for the trainees in the department, and participate in all aspects of experimental design, quality assurance, data analyses, management, and reports for departmental research projects. The Bioinformatician, Senior Research Associate will also present data and findings at lab, department, and scientific meetings, seminars, etc., prepare manuscripts and public release of data, and contribute preliminary data for grant proposals. This position functions under minimal supervision.
ESSENTIAL FUNCTIONS
Collaborate with wet lab scientists to design and refine experimental approaches to –omics studies, including statistical tests. Manage, and analyze -omics data that include but are not limited to RNA-seq, ATAC-seq, single-cell RNA-seq, single-cell multiomics, CUT&TAG, CLIP-seq, ribosome profiling, and spatially resolved gene/protein profiling. With the PIs, establish and oversee data analytics and statistical analysis goals and objectives for the efficient and timely completion of projects. Provide interpretation of various statistical and spatial/mapping outputs, develop predictions, and make recommendations to the PIs regarding study design, planning, and development. (30%)
Develop workshops and written materials to assist graduate students, postdocs, and staff in learning computational biology methodologies and programming skills; oversee the design, management, and analysis of the bioinformatic and statistical components of projects and experiments to ensure projects are completed according to the research plan. This will involve the teaching of methodologies to students, postdocs, and staff within the department. (25%)
Provide scientific oversight of bioinformatics projects, including data collection and maintenance, hypotheses, and analytical needs. Establish and manage the day-to-day priorities of the research staff in consultation with the principal investigators (PIs) and collaborators. Develop new techniques and protocols to advance research projects within the department. Assess, update, and develop new statistical standard operating procedures (SOPs) for the various departmental labs. (22%).
Prepare result summaries. Generate analysis reports including the results and documentation of the pipeline. Apply appropriate statistical methods and/or collaborate with the team to ensure statistical rigor of results. Provide data visualization for academic publications and research presentations. Present data and findings at lab, department, and scientific meetings, seminars, etc. Prepare manuscripts, and contribute preliminary data for grant proposals. (10%)
Explore novel approaches to analyze data generated by new experimental platforms. Maintain detailed records of computational code and analyses. (5%)
Co-author scientific papers. Assemble data and make publication-quality figures from analyzed data. With the highest level of integrity and responsible conduct of research, participate in writing manuscripts as a co-author for discoveries from research performed in the labs, together with the PIs and other lab members. (5%)
NONESSENTIAL FUNCTIONS
Interacting with UTech to ensure smooth operation with HPC. (2%)
Perform other duties as assigned. (1%)
CONTACTS
Department: Frequent interactions with students, postdocs, and staff in the oversight and training of methodologies. Regular interactions with PIs and other members of the department to help with data analysis support. Contact with administrative staff as needed.
University: Regular contact with collaborators in other university departments and centers. Occasional contact with the CWRU [U]Tech for computing support. Occasional contact with Research Administration and the IRB.
External: Frequent contact with researchers outside of CWRU to discuss and review experimental results.
SUPERVISORY RESPONSIBILITY
Oversee and provide direct supervision of bioinformatic projects, technical guidance, and training of trainees. May provide indirect supervision of bioinformatic staff and students.
Qualifications QUALIFICATIONS
Experience/Education: BS with 7 to 9 years of related work experience, MS with 5 to 7 years of related work experience or PhD with 3 to 5 years of postdoctoral experience in bioinformatics within biomedical research at a university, nonprofit research organization, industry, or similar setting required. BS/MS degree preferably in Genetics, Biology, Bioinformatics, Biostatistics, Computational Biology, Computer Science, or a related field. Ph.D. in biomedical sciences or bioinformatics preferred.
REQUIRED KNOWLEDGE, SKILLS and ABILITIES
Knowledge of common concepts and procedures in computer science, statistics, and bioinformatics. A strong background and understanding of molecular and cellular processes, gene expression, and general biology. Background in neuroscience is desirable.
Skills in quality control/quality assurance in laboratory and multi-disciplinary programs in bioinformatics.
Excellent skills in analytics, integration, and visualization.
Expertise working with highly complex data, performing complex analytic tasks, and formulating findings and recommendations from the analysis.
Strong programming skills required. Experience with R, Python, and other programming languages.
Strong organizational skills, and ability to multi-task, prioritize, and meet deadlines. Must demonstrate attention to detail and accuracy, time management skills, and follow-through.
Ability to work effectively independently and collaboratively within a team. Must be highly motivated, responsible, and dependable.
Ability to follow instructions and pre-established guidelines to perform the functions of the job.
Ability to meet consistent attendance.
Excellent oral and written communication skills and interpersonal skills; must demonstrate the ability to effectively and professionally communicate and work with various individuals from a broad spectrum of disciplines, and technical and educational backgrounds within the department, school, and university. Ability to interact with colleagues, supervisors, and other programmers.
Strong organization skills; ability to multi-task, prioritize, and meet deadlines. Must demonstrate attention to detail and accuracy, time management skills, and follow-through. Must be able to work under pressure and conform to shifting priorities, demands, and timeline.
Effective leadership skills; ability to lead, train, work with, and elicit cooperation from team members and staff.
Effective problem-solving skills, excellent analytical skills, sound judgment, and good decision-making.
WORKING CONDITIONS
Work in an office area in the Department of Neurosciences that hosts various experimental scientists.
No travel outside the Cleveland area is required.
Work will be done in a dry lab area with no expected exposures to hazards.
Overtime or weekend hours may be needed to fulfill projects as needed.
Physical requirements include working at a computer and the use of a mouse and keyboard.
Application Instructions Applications will include a cover letter, curriculum vitae, three reference letters, and the applicant's degree verification (a photo/copy of the candidate's highest earned degree) submitted electronically at apply.interfolio.com/173600. The position will remain posted until filled.
Department of Neurosciences Case Western Reserve University 10900 Euclid Avenue Cleveland, Ohio, 44106-4975
case.edu/medicine/neurosciences
For technical questions about your application, please contact Interfolio directly at 877-997-8807 or help@interfolio.com.
Application Process This institution is using Interfolio's Faculty Search to conduct this search. Applicants to this position receive a free Dossier account and can send all application materials, including confidential letters of recommendation, free of charge. Apply Now Equal Employment Opportunity Statement Case Western Reserve University is an equal opportunity employer. All applicants are protected under federal and state laws and university policy from discrimination based on race, color, religion, sex, sexual orientation, gender identity or expression, national or ethnic origin, protected veteran status, disability, age and genetic information.
Reasonable Accommodation Statement: Case Western Reserve University complies with the Americans with Disabilities Act regarding reasonable accommodations for applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity by phone at 216.368.3066 or by email at equity@case.edu. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.
