Python deconvolution tools for bulk RNA-seq data

Question

[AlexStar]

I’m looking for a Python package to perform cell-type deconvolution on bulk RNA-seq datasets. I work with a large number of samples from diverse tissues and sources, and my goal is to develop a Python-based pipeline that can handle this analysis on the fly, to make my life easier.

In the past, I’ve used xCell, but since it isn’t available in Python and isn’t a true deconvolution method that provides actual cell-fraction estimates, I’m now looking for alternatives. I’ve recently transitioned to using Python, so I’d really appreciate recommendations for a robust, well maintained deconvolution tool, along with guidance on how to use it effectively.

Thanks!