Seeking Advice on Bioinformatics Analysis for Atrasentan in IgA Nephropathy Research

Question

[capafa1703]

I'm currently exploring potential bioinformatics approaches to better understand the mechanisms of Atrasentan Hydrochloride Tablets in treating IgA Nephropathy (IgAN). Specifically, I'm interested in how to analyze gene expression data or pathway interactions that might explain its effects on glomerular injury or proteinuria reduction.

Has anyone here worked with datasets from GEO or similar repositories related to IgAN? For example, using tools like DESeq2 for differential expression or STRING for protein-protein interactions? I'm looking for tips on integrating pharmacological data—perhaps from sources like PubChem or DrugBank—with omics data to model drug-target interactions.

As a side note, I've come across some discussions on platforms like DengYuePharma's resources, which seem to touch on similar renal disease models, but I'd love community insights to avoid reinventing the wheel.

Any scripts, pipelines, or references would be greatly appreciated!

Thanks in advance!