User: User 6659

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User 6659970
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8 years, 5 months ago
Joined:
8 years, 6 months ago
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u1242

Posts by User 6659

<prev • 84 results • page 1 of 9 • next >
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Comment: C: How Can I Learn More About Go Ontologies?
... i agree with chris - we need a specific example of what you want to achieve ...
written 8.4 years ago by User 6659970
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Comment: C: What Is The Difference Between Sequencing Depth And Coverage
... thanks for answering. if 90% per sample per region are covered at least once and 10% of a sample are not covered then the length of the region in question surely has a huge impact on that? How is region length taken into consideration? Is there a certain coverage that ensures 100% of the genome is s ...
written 8.4 years ago by User 6659970
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Comment: C: What Is The Difference Between Sequencing Depth And Coverage
... thanks. What do you think a coverage of 90% per sample per region means as per the question i linked to? Does that mean that 90% of any particular sequence region is sequenced to any depth? That would suggest 10% of a region isn't sequenced at all which doesnt sound likely ...
written 8.4 years ago by User 6659970
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Comment: C: What Is The Difference Between Sequencing Depth And Coverage
... thanks - what do you think they mean in the question i referred to by coverage = min 90% per sample/per region ...
written 8.4 years ago by User 6659970
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What Is The Difference Between Sequencing Depth And Coverage
... Hello Please could you clarify for me the different metrics associated with sequencing data. What is the difference between depth and coverage. I have seen a question with this title closed already because it is was classed as an exact duplicate to this question. I have read that question and thou ...
read coverage sequencing written 8.4 years ago by User 6659970 • updated 8.4 years ago by Michael Dondrup46k
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Comment: C: Sift Or Polyphen
... Also what are the SNP effects in thalassemia and falciform anaemia you refer to? I'm not aware of the impact of SNPs in these diseases. Are they non synonymous SNPs? Actually the thalassemia one is ringing a dim and distant bell now you mention it :) ...
written 8.4 years ago by User 6659970
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Comment: C: Sift Or Polyphen
... sorry is that question at me or snpminer? Please can you rephrase it as if it is directed at me, I don't understand the question. Incidentally my comment was directed at the OP not at you. I thought he might be interested in the BMC paper. I'm familiar with you as a member of this forum and I didn't ...
written 8.4 years ago by User 6659970
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Comment: C: Sift Or Polyphen
... can i ask why it has to be SIFT or polyphen as it seems very restrictive and a bit unrealistic. we could perhaps help more if we knew the constraints you were operating under. However you might be interested to know that recent studies have shown that there is no link between the effect of a SNP on ...
written 8.4 years ago by User 6659970
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Answer: A: Ucsc Browser And Novel Snps
... I emailed the author of the tool and he confirmed that the tool uses genomic sequences to calculate the effects of novel variants ...
written 8.4 years ago by User 6659970
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Answer: A: Regulatory Or Nonsynonymous Snp
... To quote from a paper 'exome sequencing identifies the cause of a mendelian disorder' "the clear majority of alleleic variants known to underlie Mendelian disorders disrupt protein-coding sequences. Splice acceptor and donor sites represent an additional class of sequences that are enriched for hi ...
written 8.4 years ago by User 6659970

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