Moderator: Giovanni M Dall'Olio

Reputation:
26,160
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Location:
London, UK
Website:
http://bioinfoblog.it/
Twitter:
dalloliogm
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Google Scholar Page
Last seen:
1 week, 1 day ago
Joined:
9 years, 6 months ago
Email:
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Research Associate at the King's College of London. Interested in human population genetics and cancer.

Posts by Giovanni M Dall'Olio

<prev • 1,378 results • page 1 of 138 • next >
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Comment: C: How Do I Convert From Bed Format To Gff Format?
... HDF-5 is a generic format for big datasets, which can be used for several applications, from astrophysics to scRNA data. It's conceptually similar to a zip file containing several files and folders. As such, there is not a single way to convert it to plink - it depends on which data is inside the HD ...
written 4 months ago by Giovanni M Dall'Olio26k
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Comment: C: Why use LASSO / elastic net in survival regression?
... What about doing a PCA first, then cox or other regressions on the components? The PCA would deal with correlation among the variables. The lasso regression would penalize correlated variables and possibly remove them from the model (as they will have lower betas), but is that what you really want? ...
written 7 months ago by Giovanni M Dall'Olio26k
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Answer: A: PCA in a RNA seq analysis
... (the following is a dramatization of the reality - but is generally true. You can think of it as the legend of the PCA) For many centuries, the scientific community believed in what is written in the bible, which is that **all humans are created equals, and there are no differences between people** ...
written 8 months ago by Giovanni M Dall'Olio26k
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Comment: C: PCA in a RNA seq analysis
... If you look at the pairs plots, you will notice that there it seems to be no correlation between any of the components. That in fact is an important property of the components - there is no correlation between them. If you have a dataset containing multiple variables and some of these are correlated ...
written 8 months ago by Giovanni M Dall'Olio26k
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Comment: C: How to interpret XPEHH (recent selection) score?
... Yes, it is directional but in many cases you don't really know which is the ancestral allele or not. In that case it is safer to get the absolute score, and determine whether there is selection between the two populations, without knowing which is the allele selected. Moreover people tend to calcula ...
written 10 months ago by Giovanni M Dall'Olio26k
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Answer: A: GTEx Analysis V7 RNA-seq dataset download
... I had trouble downloading the data in the past, luckily the help desk is always very useful and they will answer in a few hours. In the end we managed to find another way to download the data using the cloud. ...
written 17 months ago by Giovanni M Dall'Olio26k
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Answer: C: as.integer function is converting row names in to number
... Explanation: your column is stored as factors Solution1: as.integer(as.character(mycolumn)) Solution2: use stringAsFactors=F when reading the data ...
written 17 months ago by Giovanni M Dall'Olio26k
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Comment: C: Boxplot in ggplot2
... This is good but I would use gather from tidyr. The package tidyr is the evolution of reshape2, and it contains more functions to massage data and reshape it for ggplot2/tidyverse. ...
written 20 months ago by Giovanni M Dall'Olio26k
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Comment: C: p-value in GSEA
... Just a clarification: the p-values did not change because of the order of genes, but because of a different random number seed. Try running the same analysis on the same set without changing the order, and the p-values will be different again. ...
written 2.0 years ago by Giovanni M Dall'Olio26k
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Comment: C: p-value in GSEA
... Moderator note: I've moved this from a comment to a reply, so it can be voted as a proper answer. ...
written 2.0 years ago by Giovanni M Dall'Olio26k

Latest awards to Giovanni M Dall'Olio

Scholar 5 weeks ago, created an answer that has been accepted. For A: How TCGA generanker works ?
Appreciated 5 weeks ago, created a post with more than 5 votes. For A: Would There Be Interest In A 'Next-Gen Sequencing' Stackexchange Site?
Great Question 7 weeks ago, created a question with more than 5,000 views. For A Database Of Signatures Of Selection In The 1000 Genomes Dataset
Epic Question 3 months ago, created a question with more than 10,000 views. For A Database Of Signatures Of Selection In The 1000 Genomes Dataset
Teacher 3 months ago, created an answer with at least 3 up-votes. For A: What Is The Input Format For Rnaplot In The Vienna Package?
Great Question 4 months ago, created a question with more than 5,000 views. For A Database Of Signatures Of Selection In The 1000 Genomes Dataset
Popular Question 5 months ago, created a question with more than 1,000 views. For A Database Of Signatures Of Selection In The 1000 Genomes Dataset
Popular Question 5 months ago, created a question with more than 1,000 views. For Computational Biologist at GSK (Stevenage, UK - between London and Cambridge)
Good Answer 7 months ago, created an answer that was upvoted at least 5 times. For A: How To Perform A Fst (Fixation Index) Calculation Over A Vcf File Using A Slidin
Good Answer 7 months ago, created an answer that was upvoted at least 5 times. For A: How Do I Convert From Bed Format To Gff Format?
Appreciated 7 months ago, created a post with more than 5 votes. For A: Would There Be Interest In A 'Next-Gen Sequencing' Stackexchange Site?
Scholar 7 months ago, created an answer that has been accepted. For A: How TCGA generanker works ?
Good Answer 8 months ago, created an answer that was upvoted at least 5 times. For A: Remove Some Snps In Plink
Appreciated 8 months ago, created a post with more than 5 votes. For A: Would There Be Interest In A 'Next-Gen Sequencing' Stackexchange Site?
Teacher 8 months ago, created an answer with at least 3 up-votes. For A: What Is The Input Format For Rnaplot In The Vienna Package?
Teacher 8 months ago, created an answer with at least 3 up-votes. For A: What Is The Input Format For Rnaplot In The Vienna Package?
Prophet 9 months ago, created a post with more than 20 followers. For A Database Of Signatures Of Selection In The 1000 Genomes Dataset
Teacher 9 months ago, created an answer with at least 3 up-votes. For A: What Is The Input Format For Rnaplot In The Vienna Package?
Good Answer 10 months ago, created an answer that was upvoted at least 5 times. For A: Why You Need Perl/Python If You Know R/Shell [Ngs Data Analysis]
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Scholar 12 months ago, created an answer that has been accepted. For A: How TCGA generanker works ?
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Appreciated 13 months ago, created a post with more than 5 votes. For C: Computing Number Of Nucleotide And Genes On Each Chromosome
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