Moderator: Jean-Karim Heriche

Reputation:
23,790
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Trusted
Location:
EMBL Heidelberg, Germany
Website:
http://jkh1.github.io/
Last seen:
17 minutes ago
Joined:
9 years, 6 months ago
Email:
h******@embl.de

Posts by Jean-Karim Heriche

<prev • 2,812 results • page 1 of 282 • next >
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Comment: C: How to choose a gene selection approach?
... The approach will depend on what you're interested in. Define what is relevant to your use case. Also if by significance you mean statistical significance, remember that it doesn't automatically mean biological relevance. ...
written 17 hours ago by Jean-Karim Heriche24k
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Comment: C: Disagreement between ROC analysis and survival analysis (log-rank test)
... I am not sure that I understand what you're doing but assuming that the ROC analysis is about predicting survival at 1, resp. 2 years, then it is not doing the same thing as the logrank test. With the ROC analysis you're testing prediction of survival at a particular time point for each group separa ...
written 2 days ago by Jean-Karim Heriche24k
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Comment: C: Non-uniform p-value histogram in differential analysis
... Yes exploring with FDRtools is worth a shot. ...
written 4 days ago by Jean-Karim Heriche24k
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Comment: C: Non-uniform p-value histogram in differential analysis
... As suggested in the linked article, the likely reason is violation of the assumptions of the statistical test that generates the p-values. For example if the test assumes independent samples but they are not then you could end up with p-values distributed like in situation D. However, I think this m ...
written 4 days ago by Jean-Karim Heriche24k
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Comment: C: Should I use Z-score standardization or Min-Max scaling in biological data ?
... As usual it depends on the data and the objective. Z-score normalization may be more useful for statistical applications while min-max normalization may be better for visualization. Note that min-max normalization can be problematic if there are outliers. ...
written 5 days ago by Jean-Karim Heriche24k
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Comment: C: Where to start? Newbie trying to enter the world of computational biology gettin
... +1 for > finding local help with this project ...
written 5 days ago by Jean-Karim Heriche24k
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Comment: C: RIP CentOS, CentOS 8 to be EOL'd in 2021
... Thanks for the heads up. It doesn't look like a viable option to replace CentOS at scale like on a whole cluster or for a fleet of VMs. ...
written 5 days ago by Jean-Karim Heriche24k
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Comment: C: Extracting the Predicted Reults of Neural network in R
... This is not a bioinformatics question but an R programming one. ...
written 7 days ago by Jean-Karim Heriche24k
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Answer: C: Thoughts regarding career paths?
... > Am I right in my assumption that I can potentially make it into the field of bioinformatics with a background in statistics and mathematics, Yes > would I need an extensive biology background as well No That's for the TL;DR. In practice, as usual, the answer is it depends, most notably o ...
written 15 days ago by Jean-Karim Heriche24k
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Comment: C: Bio.Align using smith-waterman local alignment causes memory leak
... A memory leak is a software bug. If it doesn't originate in your code but in a library you're using you should report it to the library's authors. Make sure though that it is really a memory leak and not simply large memory usage caused by having a large data set. Also note that many scripting langu ...
written 18 days ago by Jean-Karim Heriche24k

Latest awards to Jean-Karim Heriche

Commentator 5 days ago, created a comment with at least 3 up-votes. For C: How to make sure there is no duplicate sequence in a fasta file?
Scholar 5 weeks ago, created an answer that has been accepted. For A: Bonferonni Correction for mostly overlapping enhancers
Commentator 5 weeks ago, created a comment with at least 3 up-votes. For C: How to make sure there is no duplicate sequence in a fasta file?
Teacher 6 weeks ago, created an answer with at least 3 up-votes. For A: Rnai Screening Data Repositories?
Commentator 6 weeks ago, created a comment with at least 3 up-votes. For C: How to make sure there is no duplicate sequence in a fasta file?
Good Answer 7 weeks ago, created an answer that was upvoted at least 5 times. For A: Can someone give insight into the difference between current gene-function datab
Appreciated 8 weeks ago, created a post with more than 5 votes. For A: WGCNA - what is it for
Commentator 8 weeks ago, created a comment with at least 3 up-votes. For C: How to make sure there is no duplicate sequence in a fasta file?
Teacher 11 weeks ago, created an answer with at least 3 up-votes. For A: Rnai Screening Data Repositories?
Scholar 11 weeks ago, created an answer that has been accepted. For A: Bonferonni Correction for mostly overlapping enhancers
Appreciated 11 weeks ago, created a post with more than 5 votes. For A: WGCNA - what is it for
Teacher 3 months ago, created an answer with at least 3 up-votes. For A: Rnai Screening Data Repositories?
Scholar 3 months ago, created an answer that has been accepted. For A: Bonferonni Correction for mostly overlapping enhancers
Scholar 4 months ago, created an answer that has been accepted. For A: Bonferonni Correction for mostly overlapping enhancers
Librarian 5 months ago, created a post with more than 10 bookmarks. For Heatmaps in R
Good Answer 5 months ago, created an answer that was upvoted at least 5 times. For A: Can someone give insight into the difference between current gene-function datab
Commentator 5 months ago, created a comment with at least 3 up-votes. For C: How to make sure there is no duplicate sequence in a fasta file?
Scholar 5 months ago, created an answer that has been accepted. For A: Bonferonni Correction for mostly overlapping enhancers
Teacher 6 months ago, created an answer with at least 3 up-votes. For A: Rnai Screening Data Repositories?
Scholar 6 months ago, created an answer that has been accepted. For A: Bonferonni Correction for mostly overlapping enhancers
Teacher 6 months ago, created an answer with at least 3 up-votes. For A: Rnai Screening Data Repositories?
Teacher 6 months ago, created an answer with at least 3 up-votes. For A: Rnai Screening Data Repositories?

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