Moderator: Jean-Karim Heriche
Jean-Karim Heriche ♦ 24k
- Reputation:
- 23,790
- Status:
- Trusted
- Location:
- EMBL Heidelberg, Germany
- Website:
- http://jkh1.github.io/
- Last seen:
- 17 minutes ago
- Joined:
- 9 years, 6 months ago
- Email:
- h******@embl.de
Posts by Jean-Karim Heriche
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... The approach will depend on what you're interested in. Define what is relevant to your use case.
Also if by significance you mean statistical significance, remember that it doesn't automatically mean biological relevance. ...
written 17 hours ago by
Jean-Karim Heriche ♦ 24k
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... I am not sure that I understand what you're doing but assuming that the ROC analysis is about predicting survival at 1, resp. 2 years, then it is not doing the same thing as the logrank test. With the ROC analysis you're testing prediction of survival at a particular time point for each group separa ...
written 2 days ago by
Jean-Karim Heriche ♦ 24k
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... Yes exploring with FDRtools is worth a shot. ...
written 4 days ago by
Jean-Karim Heriche ♦ 24k
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... As suggested in the linked article, the likely reason is violation of the assumptions of the statistical test that generates the p-values. For example if the test assumes independent samples but they are not then you could end up with p-values distributed like in situation D. However, I think this m ...
written 4 days ago by
Jean-Karim Heriche ♦ 24k
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... As usual it depends on the data and the objective. Z-score normalization may be more useful for statistical applications while min-max normalization may be better for visualization. Note that min-max normalization can be problematic if there are outliers. ...
written 5 days ago by
Jean-Karim Heriche ♦ 24k
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... +1 for
> finding local help with this project
...
written 5 days ago by
Jean-Karim Heriche ♦ 24k
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... Thanks for the heads up. It doesn't look like a viable option to replace CentOS at scale like on a whole cluster or for a fleet of VMs. ...
written 5 days ago by
Jean-Karim Heriche ♦ 24k
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... This is not a bioinformatics question but an R programming one. ...
written 7 days ago by
Jean-Karim Heriche ♦ 24k
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... > Am I right in my assumption that I can potentially make it into the field of bioinformatics with a background in statistics and mathematics,
Yes
> would I need an extensive biology background as well
No
That's for the TL;DR. In practice, as usual, the answer is it depends, most notably o ...
written 15 days ago by
Jean-Karim Heriche ♦ 24k
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... A memory leak is a software bug. If it doesn't originate in your code but in a library you're using you should report it to the library's authors. Make sure though that it is really a memory leak and not simply large memory usage caused by having a large data set. Also note that many scripting langu ...
written 18 days ago by
Jean-Karim Heriche ♦ 24k
Latest awards to Jean-Karim Heriche
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5 days ago,
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For C: How to make sure there is no duplicate sequence in a fasta file?
Scholar
5 weeks ago,
created an answer that has been accepted.
For A: Bonferonni Correction for mostly overlapping enhancers
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5 weeks ago,
created a comment with at least 3 up-votes.
For C: How to make sure there is no duplicate sequence in a fasta file?
Teacher
6 weeks ago,
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For A: Rnai Screening Data Repositories?
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6 weeks ago,
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For C: How to make sure there is no duplicate sequence in a fasta file?
Good Answer
7 weeks ago,
created an answer that was upvoted at least 5 times.
For A: Can someone give insight into the difference between current gene-function datab
Commentator
8 weeks ago,
created a comment with at least 3 up-votes.
For C: How to make sure there is no duplicate sequence in a fasta file?
Teacher
11 weeks ago,
created an answer with at least 3 up-votes.
For A: Rnai Screening Data Repositories?
Scholar
11 weeks ago,
created an answer that has been accepted.
For A: Bonferonni Correction for mostly overlapping enhancers
Appreciated
3 months ago,
created a post with more than 5 votes.
For A: Can someone give insight into the difference between current gene-function datab
Appreciated
3 months ago,
created a post with more than 5 votes.
For A: Can someone give insight into the difference between current gene-function datab
Teacher
3 months ago,
created an answer with at least 3 up-votes.
For A: Rnai Screening Data Repositories?
Scholar
3 months ago,
created an answer that has been accepted.
For A: Bonferonni Correction for mostly overlapping enhancers
Scholar
4 months ago,
created an answer that has been accepted.
For A: Bonferonni Correction for mostly overlapping enhancers
Good Answer
5 months ago,
created an answer that was upvoted at least 5 times.
For A: Can someone give insight into the difference between current gene-function datab
Commentator
5 months ago,
created a comment with at least 3 up-votes.
For C: How to make sure there is no duplicate sequence in a fasta file?
Scholar
5 months ago,
created an answer that has been accepted.
For A: Bonferonni Correction for mostly overlapping enhancers
Appreciated
6 months ago,
created a post with more than 5 votes.
For A: Can someone give insight into the difference between current gene-function datab
Teacher
6 months ago,
created an answer with at least 3 up-votes.
For A: Rnai Screening Data Repositories?
Scholar
6 months ago,
created an answer that has been accepted.
For A: Bonferonni Correction for mostly overlapping enhancers
Teacher
6 months ago,
created an answer with at least 3 up-votes.
For A: Rnai Screening Data Repositories?
Teacher
6 months ago,
created an answer with at least 3 up-votes.
For A: Rnai Screening Data Repositories?
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