User: Nandini

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Nandini840
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Bioinformatician

Develop and maintain pipeline(s) for WES, Targeted gene sequencing, mtDNA NGS analysis

Posts by Nandini

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Comment: C: Calculate coverage from SAM file
... unfortunately not. these are really old clinical samples that have been sent across. ...
written 4 months ago by Nandini840
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Calculate coverage from SAM file
... I have a really old sam format file that does not have any header or information on what build it has been aligned to. It looks something like this NS500377:28:H16A7BGXX:3:21410:1181:5368 99 chr11 3000035 255 40M = 3000039 44 GTTTTTCACTGTTTCTCCCCATATTCCAGGTCTTACAGT ...
no header samtools sam coverage written 4 months ago by Nandini840 • updated 4 months ago by onestop_data260
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Comment: C: If the odds ratio of a SNP is < 1, does that mean the minor allele is protective
... I know this is irrelevant now but being a part of this project, I feel the need to mention that we did correct for covariates such as age, sex and principal components to adjust for possible population stratification. It is also mentioned in the methods section of the paper ...
written 10 months ago by Nandini840
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Comment: C: Convert vcf phased data to plink
... Ah, for now, I was able to sort my issue out using the R package SNPrelate. It takes in the vcf file as input, calculates IBS and then if one feels like it, it can also convert it to PLINK format ! ...
written 11 months ago by Nandini840
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Comment: C: Convert vcf phased data to plink
... still the same. I don't think PLINK can handle phased Haplotype file in the format 0|1, where 0 indicates ref and 1 is for the alt allele. Can it ? ...
written 11 months ago by Nandini840
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Comment: C: Convert vcf phased data to plink
... No, so this is what I did (playing around with a chunk of chr22) ##convert vcf to plink ./plink --vcf input_genotype.vcf --keep-allele-order --allow-extra-chr 0 --make-bed --out MyData ##tried to calculate IBS using King /king -b MyData.bed --ibs The result from above is an ...
written 11 months ago by Nandini840
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Comment: C: Convert vcf phased data to plink
... thanks Kevin, I try to do that but end up wit a file that has 0 for each individual. ...
written 11 months ago by Nandini840
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Convert vcf phased data to plink
... I have a phased haplotype format vcf file that looks like this ##fileformat=VCFv4.0 ##reference=human_b36_both.fasta ##FORMAT= #CHROM POS ID REF ALT QUAL FILTER INFO FORMAT NA12891 NA12892 NA12878 NA19239 NA19238 NA19240 22 47812545 rs576981 ...
vcf phased-haplotype plink convert written 11 months ago by Nandini840 • updated 11 months ago by Gabriel R.2.7k
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Answer: C: hg19 interval list
... maybe not on the gatk bundle site. But probably a [liftover][1] should work ? [1]: https://genome.ucsc.edu/cgi-bin/hgLiftOver ...
written 13 months ago by Nandini840
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Comment: C: Identify or update refseq transcript version on snpeff
... No, we haven't as yet. ...
written 13 months ago by Nandini840

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Popular Question 6 months ago, created a question with more than 1,000 views. For How to interpret heterozygosity rate ?
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Epic Question 6 months ago, created a question with more than 10,000 views. For Calculate z-scores from GWAS summary stats
Popular Question 8 months ago, created a question with more than 1,000 views. For How to interpret heterozygosity rate ?
Popular Question 8 months ago, created a question with more than 1,000 views. For Error in Snp set analysis using MetaSKAT
Popular Question 9 months ago, created a question with more than 1,000 views. For How to interpret heterozygosity rate ?
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Popular Question 11 months ago, created a question with more than 1,000 views. For How to interpret heterozygosity rate ?
Great Question 11 months ago, created a question with more than 5,000 views. For How to interpret heterozygosity rate ?
Popular Question 11 months ago, created a question with more than 1,000 views. For Error in Snp set analysis using MetaSKAT
Popular Question 15 months ago, created a question with more than 1,000 views. For How to interpret heterozygosity rate ?
Popular Question 17 months ago, created a question with more than 1,000 views. For How to interpret heterozygosity rate ?
Teacher 17 months ago, created an answer with at least 3 up-votes. For A: Single rare variant approaches
Popular Question 19 months ago, created a question with more than 1,000 views. For How to interpret heterozygosity rate ?
Great Question 20 months ago, created a question with more than 5,000 views. For How to interpret heterozygosity rate ?
Great Question 20 months ago, created a question with more than 5,000 views. For Calculate z-scores from GWAS summary stats
Popular Question 20 months ago, created a question with more than 1,000 views. For How to interpret heterozygosity rate ?
Popular Question 20 months ago, created a question with more than 1,000 views. For How to interpret heterozygosity rate ?
Epic Question 23 months ago, created a question with more than 10,000 views. For Pros and cons of Illumina HiSeq and Next Seq
Popular Question 2.1 years ago, created a question with more than 1,000 views. For extract SNPs from compressed PLINK files
Popular Question 2.1 years ago, created a question with more than 1,000 views. For How to interpret heterozygosity rate ?
Popular Question 2.2 years ago, created a question with more than 1,000 views. For How to interpret heterozygosity rate ?
Great Question 2.2 years ago, created a question with more than 5,000 views. For Pros and cons of Illumina HiSeq and Next Seq
Appreciated 2.2 years ago, created a post with more than 5 votes. For A: How To Revert Allele Data To Atgc With Plink After Recoding To 12 Format
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