User: discombobulated

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Posts by discombobulated

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Answer: A: What should be reported as Hazard Ratio in Kaplan Meier curve?
... looking at your output, low has been coded as 1 (your outcome) and high as 0 (the reference). So you are correct that the hazard ratio is reported for Low - i.e HR of Low is 0.06. As the HR is less than 1, Low has a hazard reduction. While it is often reported as risk, technically this is not corre ...
written 11 months ago by discombobulated10
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Answer: A: What should be reported as Hazard Ratio in Kaplan Meier curve?
... Hi. Yes you are correct but you need to be careful in how you explain it. Your hazard ratio is 0.05 (ie 0.05:1) but you reduce your hazard by a factor of 95% (ie your hazard ratio as such hasn't decreased). It is only a nuance but it changes the meaning. I suggest reporting the hazard ratio (HR = 0. ...
written 12 months ago by discombobulated10
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Answer: A: Odd Ratio calculation in plink
... In the interest of learning you can test your theory by implementing the --beta flag into your analysis. This will return the regression coefficients. plink --bfile mydata --logistic --beta ...
written 12 months ago by discombobulated10
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Answer: A: Odd Ratio calculation in plink
... Basically they use different methods for the calculation of the odds ratio - logistic uses the logistic regression model and assoc uses allele counts. Your differences aren't that large but the rarer the allele the greater the difference you may see. Have a read of Plink 1.07 manual - it is outlined ...
written 12 months ago by discombobulated10
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Answer: C: How is the Bolt LMM INFO Score calculated?
... Thanks [genomax][1]. I did as you suggested and contacted the developer. It is calculated using the formula developed by[ \[Marchini and Howie\]][2] in their 2010 Nature Review Genetics paper. [1]: https://www.biostars.org/u/18713/ [2]: https://www.nature.com/articles/nrg2796 ...
written 12 months ago by discombobulated10
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How is the Bolt LMM INFO Score calculated?
... Hi I am trying to find what exactly does the INFO score from the results of [Bolt LMM][1] measure (there is nothing in the user manual and google has come up empty). I am assuming that it refers to the imputation accuracy taken from the genotype probabilities but does anyone have a link or know wha ...
bolt lmm written 12 months ago by discombobulated10 • updated 12 months ago by Pierre Lindenbaum133k

Latest awards to discombobulated

Scholar 12 months ago, created an answer that has been accepted. For C: How is the Bolt LMM INFO Score calculated?

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