User: Fadoua

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Posts by Fadoua

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Comment: C: Correcting the Negative beta coefficient (genetic risk score )
... Thank you for your reply. Actually I am willing to conduct an MR, using genetics variants as instrumental variables in order to infer causality between my exposure of interest and my target outcome. but first, I need to construct a PRS using summary data from a GWAS. the issue here is that in the o ...
written 6 weeks ago by Fadoua 0
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Comment: C: Validatingm Polygenic Risk Scores from PRSice
... Hello, I was hoping to know more about how to fix the negative beta. I think the negative beta means that the coded allele is reverse. for example: if you have some negative beta in your base GWAS data, and the ref allele is the opposite in your target population, maybe before constructing PRS, you ...
written 6 weeks ago by Fadoua 0
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Correcting the Negative beta coefficient (genetic risk score )
... Hi Dear all, I am trying to create a weighted genetic risk score model. However, The GWAS from where I got the SNP associated with the exposure factor, contained some SNPs that have a negative Beta coefficient; when I compare to my data the coded allele is reverse. how can I correct this before s ...
beta coefficient coding allele reverse snp written 6 weeks ago by Fadoua 0

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