User: Christophe Dessimoz

Reputation:
410
Status:
Trusted
Location:
University College London
Website:
http://lab.dessimoz.org/
Twitter:
cdessimoz
Scholar ID:
Google Scholar Page
Last seen:
2 months, 1 week ago
Joined:
3 years, 11 months ago
Email:
c*********@ucl.ac.uk

Posts by Christophe Dessimoz

<prev • 28 results • page 1 of 3 • next >
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Comment: C: OMA current state and its updates
... The updated OMA algorithm paper is now available: [http://doi.org/10.1093/bioinformatics/btx229][1] [1]: http://doi.org/10.1093/bioinformatics/btx229 ...
written 9 weeks ago by Christophe Dessimoz410
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Comment: C: How to make ortholog table with Reciprocal Best Hit blast (Python?) ?
... Conceptually, the main limitation of reciprocal best hit is that it cannot cope with one-to-many or many-to-many orthology, which exist whenever a gene has duplicated after the speciation of interest. More discussion here: https://academic.oup.com/gbe/article/5/10/1800/520875/Bidirectional-Best-Hit ...
written 12 weeks ago by Christophe Dessimoz410
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Answer: A: How to find orthologs in both complete and fragmented genomes using OMA Standalo
... Although OMA standalone and ESPRIT run within the same software, they have different purposes and for the moment we don't provide a unified pipeline between the two. This means that you have to take a two step process: 1. Run ESPRIT to identify likely split genes (which is what you appear to have ...
written 6 months ago by Christophe Dessimoz410
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Answer: A: OMA current state and its updates
... Hi Natasha, 1. Smith-Waterman alignments are necessarily more sensitive than blast alignments. The reason you might get more hits is likely due to differences in length and minimum score thresholds. You can play with these parameters in OMA Standalone (but as you hint, lowering fa ...
written 6 months ago by Christophe Dessimoz410
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Comment: C: [OMA] When input sequence data are DNA, OMA conversion in AA ?
... We recommend using protein sequences, because we have done much more benchmarking on this type of data. There are practical advantages too: public genomes exported from OMA, including precomputed all-against-all, are only available at for protein sequences. By contrast, the DNA-level comparison supp ...
written 9 months ago by Christophe Dessimoz410
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Answer: A: [OMA] When input sequence data are DNA, OMA conversion in AA ?
... No, OMA does not translate DNA into AA. While it's true that Gonnet PAM matrices were defined on amino-acid, it's also possible to derive empirical scoring matrices from DNA in the same way. In OMA standalone, if the input data type is DNA, we use such matrices to perform alignment and evolutionary ...
written 9 months ago by Christophe Dessimoz410
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Job: Faculty positions in Computational Biology and Human Genetics at UCL
... **Lecturer/Senior Lecturer in Computational Biology & Lecturer/Senior Lecturer in Human Genetics** The [UCL Genetics Institute (UGI)][1] is an internationally leading centre for research and teaching in genetics and genomics. It is part of the Research Department of [Genetics, Evolution and Env ...
jobs europe london faculty job rna-seq written 9 months ago by Christophe Dessimoz410
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News: The Gene Ontology Handbook (open access)
... Have you ever used the GO? Of course you have! Every bioinformatician worth their salt has on occasions been guilty of performing one GO enrichment analysis or ten. And in so doing, did you have the nagging feeling that you did not quite fully understand the ins and outs of what you were doing? If ...
news training handbook go tutorial written 9 months ago by Christophe Dessimoz410
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Answer: A: [OMA] If my jobs stop (SGE) will the results be conserved (AllvsAll) in the cach
... The work chunks that have finished computing will be reused—it does not matter what job scheduler you used or if you even used one in the first place. These are the gzipped files in the Cache/AllAll folder. However, if the SGE run was interrupted, there might be some chunks that are incomplete and ...
written 10 months ago by Christophe Dessimoz410
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Answer: A: Is it possible to run the GETHOGs algorithm on already computed pairs of ortholo
... If you don't want to run OMA standalone, you can download all HOGs from the current OMA release—the file ("Hierarchical Orthologous Groups") is linked from this page: http://omabrowser.org/oma/current/ To parse this file and retrieve HOGs defined at the various levels, I recommend that you use this ...
written 10 months ago by Christophe Dessimoz410

Latest awards to Christophe Dessimoz

Scholar 6 months ago, created an answer that has been accepted. For A: Details of OMA Running Process - OMA standalone
Scholar 6 months ago, created an answer that has been accepted. For A: Can OMA calculate orthologs for single query sequence?
Teacher 6 months ago, created an answer with at least 3 up-votes. For A: Details of OMA Running Process - OMA standalone
Appreciated 9 months ago, created a post with more than 5 votes. For The Gene Ontology Handbook (open access)
Scholar 20 months ago, created an answer that has been accepted. For A: Details of OMA Running Process - OMA standalone
Popular Question 22 months ago, created a question with more than 1,000 views. For (Senior) Research Associate In Bioinformatics And Comparative Genomics At Ucl, London
Scholar 22 months ago, created an answer that has been accepted. For A: Details of OMA Running Process - OMA standalone
Teacher 22 months ago, created an answer with at least 3 up-votes. For A: Details of OMA Running Process - OMA standalone
Scholar 23 months ago, created an answer that has been accepted. For A: Details of OMA Running Process - OMA standalone
Teacher 23 months ago, created an answer with at least 3 up-votes. For A: Details of OMA Running Process - OMA standalone

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