User: Christophe Dessimoz
Christophe Dessimoz • 410
- Reputation:
- 410
- Status:
- Trusted
- Location:
- University College London
- Website:
- http://lab.dessimoz.org/
- Twitter:
- cdessimoz
- Scholar ID:
- Google Scholar Page
- Last seen:
- 1 week, 5 days ago
- Joined:
- 3 years, 9 months ago
- Email:
- c*********@ucl.ac.uk
Posts by Christophe Dessimoz
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Comment:
C: OMA current state and its updates
... The updated OMA algorithm paper is now available: [http://doi.org/10.1093/bioinformatics/btx229][1]
[1]: http://doi.org/10.1093/bioinformatics/btx229 ...
written 12 days ago by
Christophe Dessimoz • 410
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... Conceptually, the main limitation of reciprocal best hit is that it cannot cope with one-to-many or many-to-many orthology, which exist whenever a gene has duplicated after the speciation of interest. More discussion here:
https://academic.oup.com/gbe/article/5/10/1800/520875/Bidirectional-Best-Hit ...
written 27 days ago by
Christophe Dessimoz • 410
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... Although OMA standalone and ESPRIT run within the same software, they have different purposes and for the moment we don't provide a unified pipeline between the two. This means that you have to take a two step process:
1. Run ESPRIT to identify likely split genes (which is what you appear to have ...
written 4 months ago by
Christophe Dessimoz • 410
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... Hi Natasha,
1. Smith-Waterman alignments are necessarily more sensitive than
blast alignments. The reason you might get more hits is likely due
to differences in length and minimum score thresholds. You can play
with these parameters in OMA Standalone (but as you hint, lowering
fa ...
written 4 months ago by
Christophe Dessimoz • 410
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... We recommend using protein sequences, because we have done much more benchmarking on this type of data. There are practical advantages too: public genomes exported from OMA, including precomputed all-against-all, are only available at for protein sequences. By contrast, the DNA-level comparison supp ...
written 7 months ago by
Christophe Dessimoz • 410
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... No, OMA does not translate DNA into AA.
While it's true that Gonnet PAM matrices were defined on amino-acid, it's also possible to derive empirical scoring matrices from DNA in the same way. In OMA standalone, if the input data type is DNA, we use such matrices to perform alignment and evolutionary ...
written 7 months ago by
Christophe Dessimoz • 410
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... **Lecturer/Senior Lecturer in Computational Biology & Lecturer/Senior Lecturer in Human Genetics**
The [UCL Genetics Institute (UGI)][1] is an internationally leading centre for research and teaching in genetics and genomics. It is part of the Research Department of [Genetics, Evolution and Env ...
written 8 months ago by
Christophe Dessimoz • 410
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... Have you ever used the GO? Of course you have! Every bioinformatician worth their salt has on occasions been guilty of performing one GO enrichment analysis or ten. And in so doing, did you have the nagging feeling that you did not quite fully understand the ins and outs of what you were doing?
If ...
written 8 months ago by
Christophe Dessimoz • 410
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... The work chunks that have finished computing will be reused—it does not matter what job scheduler you used or if you even used one in the first place. These are the gzipped files in the Cache/AllAll folder.
However, if the SGE run was interrupted, there might be some chunks that are incomplete and ...
written 8 months ago by
Christophe Dessimoz • 410
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... If you don't want to run OMA standalone, you can download all HOGs from the current OMA release—the file ("Hierarchical Orthologous Groups") is linked from this page: http://omabrowser.org/oma/current/
To parse this file and retrieve HOGs defined at the various levels, I recommend that you use this ...
written 8 months ago by
Christophe Dessimoz • 410
Latest awards to Christophe Dessimoz
Scholar
4 months ago,
created an answer that has been accepted.
For A: Details of OMA Running Process - OMA standalone
Scholar
4 months ago,
created an answer that has been accepted.
For A: Can OMA calculate orthologs for single query sequence?
Teacher
4 months ago,
created an answer with at least 3 up-votes.
For A: Details of OMA Running Process - OMA standalone
Appreciated
8 months ago,
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For The Gene Ontology Handbook (open access)
Scholar
18 months ago,
created an answer that has been accepted.
For A: Details of OMA Running Process - OMA standalone
Popular Question
20 months ago,
created a question with more than 1,000 views.
For (Senior) Research Associate In Bioinformatics And Comparative Genomics At Ucl, London
Scholar
20 months ago,
created an answer that has been accepted.
For A: Details of OMA Running Process - OMA standalone
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For A: Details of OMA Running Process - OMA standalone
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21 months ago,
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For A: Details of OMA Running Process - OMA standalone
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21 months ago,
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For A: Details of OMA Running Process - OMA standalone
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