What Sites Exist To Describe Rules For Proteases

Question

[Niallhaslam]

I am interested in knowing the rules for how proteases recognise and cleave their target proteins. Peptide cutter provides an extensive list here: web.expasy.org/peptidecutter/peptidecutterenzymes.html

E.g. Arg-C needs an Arginine at Position 1 - just before the cleavage site. Arg-C proteinase - - - R - -

I was wondering if anyone knows of other similar lists of rules?

Answer 1

[Pierre Lindenbaum]

There is a (downlodable) peptidase database: http://merops.sanger.ac.uk/

e.g: http://merops.sanger.ac.uk/cgi-bin/pepsum?id=A01.001

pattern: -/-/-/fScissile bond-/-/l/- (based on 207 cleavages)