Noise Model In Gene Expression Data
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9.8 years ago
Jessica ▴ 60

Hi all,

I was told by a bioinformatician that given a butch of microarray profiles, the genes with large magnitudes are more variable than genes with low magnitudes. Noise in gene expression is modelled by a poisson distribution. While this makes intuitive sense, I was not able to find a reference. Does anybody know a reference for this statement?

Thank you very much.

WQ

microarray model • 2.1k views
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Hi Wendy, Neil's suggestion was a good one. Looks like this is the reference you want: http://www.pnas.org/content/99/22/14031.full

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I just popped "microarray noise poisson" into Google Scholar. There are lots of references.

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9.8 years ago
Ahill ★ 1.9k

A well known reference in this area is Rocke, Durbin 2001.

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Thank you ahill

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