Hi I am looking for some pointers towards machine learning approaches that have been used so far in predicting "origins of replication" and would it be worthwhile going at this problem because of the tremendous data that has been made available by Next generation sequencing. And if not what makes this problem so intractable in vertebrates.
Actually I went through this paper.
And I was thinking if roadmap epigenomics data could be utilized to add on to above approach in Human. I am not sure if it's an intractable idea/ even worth trying from a machine learning perspective. Thus just wanted to think out loud!