I am having a question about hyper mutations.
While I am reading a paper (http://www.nature.com/nature/journal/v500/n7463/full/nature12477.html)
the terminology (localized substitution hypermutations) is something strange to me. Even though I searched it on the Internet, but I failed to fully understand its concept. There are too many articles and web pages related to its definition and explanation.
What I didn't understand is below sentence in the paper.
Foci of localized substitution hypermutation, termed kategis after the Grrek for thunderstorm were recently described in breast cancer.
It is hard to know what is localized substitution hyper mutation.
I really appreciate it if you help me understand its concept :)