transcription factor binding site

Question

[bioinfo]

Hi I am using oPOSSUM for my analysis. I have got some transcription factors with Z-score greater than 10 but fisher score is more than 3. I have gone through the help page, here they have given that for significant TFs Z-score should be greater than 10 and fisher score less than 0.01. I have a doubt whether i can take the significant TFs only based on Z-score or not ??

Answer 1

[m.malkowska]

Have you read this paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142402/ ?