Question: Immunoglobulins in RNA-seq results
gravatar for grp2009
3.1 years ago by
grp200920 wrote:

I am working with some RNA-seq results from mice - specifically, a comparison of infected and naive mice. Among the differentially expressed genes are numerous immunoglobulin variable regions - Igkv8-27, Ighv13-2, Igkv10-94, and so forth. Do these identifiers give me any useful information about the antibodies being produced? More generally, using the RNA-seq data (possibly going back to the FASTQ files) is there any way to learn anything about the antibodies being produced, and perhaps even the corresponding epitopes?

rna-seq sequence • 825 views
ADD COMMENTlink written 3.1 years ago by grp200920

Did you further explore this issue? I too am analyzing an RNA-seq dataset where I have many immunoglobulins differentially expressed and would like a direction to better delineate their roles.

ADD REPLYlink written 23 months ago by Iván20

So far I have not found anything interesting that can be done with these genes, but I haven't kept looking.

ADD REPLYlink written 21 months ago by grp200920
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