Fastsimcoal for transcriptome data

Question

[biobudhan]

Hello,

Is it possible/ good idea to use fastsimcoal to infer demography using transcriptome data ?

[microfuge]

Fastsimcoal generates simulated data. Not an expert but I would not be very comfortable with using transcriptome data for demography as accurate SNP calling is a challenge (uneven coverage due to differences in expression, errors in RTPCR, allelic imbalance etc) and exonic regions are under selection.