Question: Estimating heritability using GCTA or LDAK in an admixed population
gravatar for GabrielMontenegro
2.3 years ago by
United Kingdom
GabrielMontenegro500 wrote:

I have GWAS SNP data for an admixed population and I would like to estimate the heritability of my trait under study. I am using LDAK and GCTA to estimate the heritability. However, most studies that I've seen involve homogeneous populations without population structure.

Is there a way to (reliably) estimate heritability taking into account the population structure in my sample?

gcta admixture heritability • 1.3k views
ADD COMMENTlink modified 18 months ago by akang90 • written 2.3 years ago by GabrielMontenegro500
gravatar for akang
18 months ago by
akang90 wrote:

You can use kinship matrix or GRM which accounts for population structure. For LDAK see –calc-kins-direct and for GCTA see --grm.

ADD COMMENTlink written 18 months ago by akang90
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