Question: Is baseml (PAML) suitable for ancestral reconstruction of non-coding sequences?
gravatar for memory_donk
3.9 years ago by
memory_donk310 wrote:

Hi Biostars,

I'm not super familiar with the underlying data used to general substitution models or how programs like PAML utilise them for ancestral reconstructions. I'm hoping though, to do ancestral reconstructions of several non-coding (putative enhancer) sequences and wasn't sure whether PAML's substitution models are only geared toward protein-coding sequences (which would probably look quite different in terms of substitution patterns). If anyone knows which models would be best for this purpose (if any in PAML) or a program that would be more appropriate I'd greatly appreciate it.

ADD COMMENTlink written 3.9 years ago by memory_donk310
Please log in to add an answer.


Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 1080 users visited in the last hour