Question: understanding topGO enrichment
0
gravatar for michael.steffen
2.4 years ago by
michael.steffen0 wrote:

I am trying to understand how topGO decides a GO term is enriched. Specifically, I am trying to understand how terms not in my list (universal or my genes of interested with annotated GO terms) can be considered significant.

Like the example below. That GO ID is not in any of my lists, so how is it significant?

GO.ID Term Annotated Significant Expected classicFisher
GO:0009235 cobalamin metabolic process 1 1 0.03 0.02536

Thanks, Mike

R • 1.5k views
ADD COMMENTlink written 2.4 years ago by michael.steffen0
3

My guess would be that GO:0009235 is a parent term inferred from one of the terms annotated for your genes.

ADD REPLYlink written 2.4 years ago by Lars Juhl Jensen11k
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