Statistical approach to identifying outliers in RNAseq data?
Entering edit mode
4.1 years ago
Lina F ▴ 200

Hi All,

I am looking at a larger RNAseq dataset (144 samples) and I did some exploratory data analysis to look at clustering. From the PCA plot, it looks like there is a sample that clusters with a different group than expected (see the blue dot below among all the red dots). Based on this figure, I'd probably flag this as an outlier. I have four replicates for this sample, so losing one is probably fine if it improves the overall results.

What is the appropriate statistical approach to detect outliers in a more rigorous way?

Thanks for any insight!

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RNA-Seq outliers detection statistics • 1.6k views

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