Entering edit mode
6.9 years ago
griffincalme
•
0
Say that you find two orthologous peptide sequences using a tool like OMA or EMBL, you also have all of the positions of phosphosites for those two peptides (e.g. 'LKYETEDGF', pY3 & 'AKRELKYETEGFK', pY7).
What would the optimal (or even an acceptable) method of determining these sites to be orthologous?
Should you do a global alignment and then check if the new positions in the aligned sequences match up? Or a local alignment around each phosphosite? Or something else?
