Question: How do I build a centroid-based predictor for clustering gene expression data (microarray)?
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gravatar for nerfherder
20 months ago by
nerfherder0
nerfherder0 wrote:

I'm trying to assign breast cancer intrinsic subtypes to a cohort of tumor samples using an expression dataset (microarray). I've clustered the samples into subtypes using the PAM50 centroid-based predictor, but I'm interested in assigning the claudin-low subtype as well (not included in PAM50). I have the list of ~800 genes whose expression can predict this subtype, yet I'm not sure how to create the centroid-based predictor using this gene list.

Any advice or references would be much appreciated, thanks!

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