Question: PCA matching controls with cases using genotypes
gravatar for Floris Brenk
2.9 years ago by
Floris Brenk940
Floris Brenk940 wrote:

Hi there,

I have a relatively small dataset of cases (n=~800) and a very large amount of controls (n=~8000) in plink format. Now I would like to have the case-control ration 1:3 for further analysis. I was wondering is there a method or are there scripts available that perform some kind of PCA matching of controls to create a more homogenous population or is just random sampling the normal way to go... I tried filtering controls based on e.g. 3SD but not many controls were removed then suggesting the data is already pretty homogenous..

plink pca • 860 views
ADD COMMENTlink modified 2.9 years ago • written 2.9 years ago by Floris Brenk940
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