Hi all I have question about normalization of Single Nucleotide Variation number based on chromosome length. You know in variant discovery project many variants are generated in all chromosomes. but the distribution of variants are not equal between chromosomes. for example chromosome one is the biggest chromosome in genome clearly the most variants are on chromosome one. in this way, it doesn't mean chromosome one has important regions for our plan. So how can I standard of variants counts based on chromosome length? actually i want to identify chromosome, which has most the variants. Do you have any idea about this formula (variant counts/chromosome length Mb)? is it correct or do you have reference for that? seemingly this is the easiest way!!!!! I would be glad if you have any idea. thanks
