what is the lowest coverage the human genome can be sequenced at to provide roughly the same resolution as SNP6?

Question

[senowinski]

What depth of coverage of the human genome would roughly provide the same copy number resolution of SNP6?

I want to know this so that I can calculate some kind of a b-allele-frequency at roughly the same frequency as SNP6? Where let's say there is a probe every ~0.00189Mb, would this mean a minimum depth of coverage of 2x? If there are gains and losses this would mean the allele frequency could then be calculated from bps where there are 4 reads mapped?

Thoughts please!

Thanks

Answer 1

[Brian Bushnell]

2x sounds reasonable to me. To get an exact number, you should run a simulation at various levels of coverage and see what kind of sensitivity you get.